Discussion of the Preparation

A 1% concentration of chloral hydrate causes a melting point depression of 0.1 °C, which is a limited value. In the preparation of 1 g suppositories containing 4% chloral hydrate, the melting point depression is consequently 0.4 °C. This effect is minor, suggesting that a standard universal suppository base can likely be used.

If the suppositories lack sufficient firmness, 40 mg of wax may be added per suppository. The preparation method requires no special procedures, as chloral hydrate dissolves in the suppository base. Since chloral hydrate can corrode metal, the use of metal tools and metal suppository molds should be avoided.

Packaging and Storage

When suppositories are stored loose in a jar, they may become moist. The use of plastic strips is recommended for packaging, which should then be stored in a well-sealed glass jar.