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Die Rezeptur‑Helpdesk enthält mehr als 1500 Fragen und Antworten zu verschiedenen galenischen Themen, alle bereitgestellt von Prof. R. Kinget.
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Can sodium bicarbonate be added to a nasal ointment containing 200 mg eucalyptol, 300 mg ephedrine DL base (which may be replaced by ephedrine HCl), 5 drops of adrenaline tartrate ampoule (1 mg), 20 g white vaseline, and 10 g sweet almond oil, or should it be omitted—similar to borax—to prevent an alkaline environment that destabilizes adrenaline, and is the bicarbonate still necessary to neutralize the acidity of ephedrine HCl for the nasal mucosa; additionally, is white vaseline appropriate for a nasal ointment or is yellow vaseline preferred?
What is the necessary composition for a carbomer gel containing 1% clindamycin HCl and 0.1% triamcinolone acetonide to achieve the most stable preparation possible?
A doctor requests the preparation of suppositories with isosorbide dinitrate; what is the usual concentration and which suppository base can be used for this purpose?
How can 30 suppositories containing 5 mg of beclomethasone dipropionate be formulated using the softest possible suppository base to ensure they dissolve as quickly as possible?
What is a suitable replacement for a prehistoric disinfecting and drying powder formula intended for a young man with subcutaneous acne on his back, specifically containing sulfur but no skin antibiotics (such as erythromycin or clindamycin), given that the original prescription included 3% colloidal sulfur (unavailable), 0.5 g hexachlorophene (unavailable), 5 g magnesium stearate, 5 g light magnesium carbonate, 2 drops of rose oil, and talc up to 100 g?
Is it normal for the 'water-free carbomer gel' from the TMF not to be clear?
What are the stability problems of a solution containing 3 grams of Phenobarbital sodium and purified water up to 300 cc?
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