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The compounding helpdesk contains more than 1500 questions and answers on various galenic topics, all provided by Prof. R. Kinget.
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How can a shampoo for dogs and cats containing 2% w/v miconazole nitrate and 2% w/v chlorhexidine gluconate be formulated using the best form of miconazole, and what are the methods to maintain it in a stable suspension?
Which formulation is best for a preparation containing 30 g Cutivate, 10 g urea, and cold cream (Pannoc) up to 100 g, given that Cutivate cream and cold cream are unstable together while Cutivate ointment and cold cream are stable, but the fluticasone concentration in the ointment is ten times lower and the ointment is reportedly more potent than the cream?
How should hexachlorophene be optimally processed and must it be kept in solution for a 200 ml shampoo containing 1.5% zinc pyrithione and 0.5% hexachlorophene, given that the zinc pyrithione is suspended in a shampoo simplex based on Texapon NSO thickened with NaCl, and the hexachlorophene causes additional thickening?
How should a sterile ear drop solution containing 100,000 IU Polymyxin B, 50 mg Chloramphenicol, 5 ml Propylene Glycol, 5 ml Water, and 50 mg Hydrocortisone be prepared for a patient prescribed 2 drops in both ears 3 times daily for 7 days, and can Hydrocortisone Sodium Phosphate be replaced by Hydrocortisone Acetate since the phosphate form is no longer available?
Do you have any information regarding the degradation of corticosteroid esters by zinc oxide?
Since the Therapeutic Magistral Formulary (TMF) recommends triturates for corticosteroid preparations, but creating these with micronized powders causes significant issues due to electrostatic forces, is it acceptable to add 1% talc as an anti-static agent to improve the powder's manipulability, rather than simply mixing with mannitol or lactose?
What are the stability problems of a solution containing 3 grams of Phenobarbital sodium and purified water up to 300 cc?
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