Question
Gepost op: 29 March 2026What is the recommended water-to-vaseline ratio for the magistral preparation of Pliaglis cream (containing 70.000 mg lidocaine, 70.000 mg tetracaine, 0.500 mg methyl parahydroxybenzoate, 0.100 mg propyl parahydroxybenzoate, calcium hydrogen phosphate, purified water, polyvinyl alcohol, white vaseline, and sorbitan palmitate) for a dermatologist's request to provide maximum anesthesia on a large surface area like the back during laser treatment, or can AVA be used instead with an equally strong numbing effect on the skin?
Answer
Gepost op: 29 March 2026Discussion of the preparation
The specified composition relates to 1 g of cream. To achieve a homogeneous distribution in the cream, the "caines" must be diluted with an inert filler (see composition).
The use of AVA is a possibility for this.
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