Question
Gepost op: 29 marzo 2026What is the correct procedure for incorporating salicylic acid into a corticosteroid-containing ointment consisting of 0.05% clobetasol dipropionate, 30 g TMF hydrophobic ointment, 40 g Unguentum simplex, 10 g talc, 10 g zinc oxide, 2 g salicylic acid, and aqua dist. q.s., given that the physician specified adding water until saturation when asked about the total volume?
Answer
Gepost op: 29 marzo 2026Discussion of the Preparation
Dissolving 2 g of salicylic acid in water at 20°C requires 1 liter of water, which is unrealistic in this context. Furthermore, when salicylic acid is brought into solution, a reaction occurs with zinc oxide (ZnO), forming zinc salicylate. In the Therapeutic Magistral Formulary (TMF), salicylic acid is often added to fatty ointments with corticosteroids to improve absorption. In such cases, the salicylic acid is added undissolved to the fatty ointment base.
Based on these data, it is recommended to remove the water from the composition. The total mass of the preparation currently amounts to 92 g. To reach a total of 100 g, the amount of unguentum simplex can be increased to 48 g.
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