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De helpdesk bevat meer dan 1500 vragen en antwoorden over diverse galenische topics, allemaal aangeleverd door Prof. R. Kinget.
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Is metronidazole heat-stable and can a 2% metronidazole eye ointment without wool fat be sterilized for 1 hour at 150°C to achieve a preparation that is as sterile as possible for application to the eyelids, given that filtration is not an option due to its slight solubility in water, alcohol, acetone, and dichloromethane according to Ph. Eur. 10?
Given that naphazoline is used as a vasoconstrictor in pantocaine nasal spray but is currently out of stock, can xylometazoline be used as an alternative, and if so, is it used in a 1:1 ratio and compatible with pantocaine?
What alternative can be used for Alucol in a preparation containing disulfiram and Alucol, now that Alucol is no longer available?
Are there conversion tables available for converting powders to extracts, specifically for substances like Aloe, Cascara, Rheum, and Senna, similar to those found for Fucus?
Is it possible to prepare vaginal boric acid capsules that are compatible with latex condoms and are therefore not oil-based ovules?
What is the best method to dissolve a preparation containing 10% salicylic acid and 0.121% betamethasone valerate in medicinal oil up to 250 ml, specifically to prevent salicylic acid from recrystallizing after being heated in isopropyl myristate and mixed with sweet almond oil, and is the concentration of salicylic acid too high to remain in solution?
Regarding capsule sizes for small quantities, is it legally required to use at least a size 2 capsule when weighing out amounts of less than 10 mg of a substance, or is size 4 also permitted?
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